Pepinh-TRIF
| Pepinh-TRIF | Unit size | Cat. code | Docs | Price |
|---|---|---|---|---|
TRIF inhibitory peptide | 2 mg | tlrl-pitrif | TDSMSDS | Please contact our distributor Add to favorite |
- About
- Specifications
- Contents
- Citations
TRIF inhibitory peptide
Pepinh-TRIF is a 30 aa peptide that blocks TRIF signaling by interfering with TLR-TRIF interaction.
PepinhTRIF contains the 14 aa that correspond to the sequence of the BB loop of TRIF (FCEEFQVPGRGELH) [1] linked to the cell-penetrating segment of the antennapedia homoedomain (RQIKIWFQNRRMKWKK) [2].
Pepinh TRIF is provided with Pepinh-Control, a control peptide [1].
References:
1. Toshchakov V. et al., 2005. Differential Involvement of BB Loops of Toll-IL-1 Resistance (TIR) Domain-Containing Adapter Proteins in TLR4- versus TLR2-Mediated Signal Transduction. J. Immunol., 175: 494 - 500.2. Derossi D. et al., 1994. The third helix of the Antennapedia homeodomain translocates through biological membranes. J. Biol. Chem., 269: 10444-50.
Back to the topSpecifications
Working concentration: 5-50 μM
Purity: ≥95% (UHPLC)
Species reactivity: Human, mouse
Sequences:
- Pepinh-TRIF: RQIKIWFQNRRMKWKK-FCEEFQVPGRGELH-NH2
(TRIF homodimerization sequence is underlined)
- Pepinh-Control: RQIKIWFQNRRMKWKK-SLHGRGDPMEAFII-NH2
Molecular weights:
- Pepinh-TRIF: 3918
- Pepinh-Control: 3812
Contents
Pepinh-TRIF is provided as a white solid .
- 2 mg of lyophilized Pepinh-TRIF
- 2 mg of lyophilized Pepinh-Control
- 2x1.5 ml endotoxin-free water
Pepinh-TRIF is shipped at room temperature.
Store at -20°C.
Solid product is stable 1 year at -20°C.
Upon resuspension, Pepinh-TRIF should be aliquoted and stored at -20°C.
Avoid repeated freeze-thaw cycles.
Resuspended product is stable for 6-8 months at -20°C when properly stored.
Back to the topCitations
2019 BJC DOI: 10.1038/s41416-019-0595-2
Tumour cell-derived debris and IgG synergistically promote metastasis of pancreatic cancer by inducing inflammation via tumour-associated macrophages.
Chen Q. et al.
2018 J Immunol. 200(10):3599-3611.
The Synergy between Palmitate and TNF-α for CCL2 Production Is Dependent on the TRIF/IRF3 Pathway: Implications for Metabolic Inflammation.
Ahmad R. et al.
2012 J Neurosci. 32(22):7745-7757
Toll/interleukin-1 receptor domain-containing adapter inducing interferon-β mediates microglial phagocytosis of degenerating axons.
Hosmane S, Tegenge MA, Rajbhandari L, Uapinyoying P, Kumar NG, Thakor N, Venkatesan A
2011 PLoS ONE 6(9):e25504
Leukocyte- and platelet-derived microvesicle interactions following in vitro and in vivo activation of toll-like receptor 4 by lipopolysaccharide.
Xiong J, Miller VM, Hunter LW, Li Y, Jayachandran M
Load more
